首页>
外国专利>
Pyrimidylamino-benzamide derivatives for the treatment of neuro-fibromatosis
Pyrimidylamino-benzamide derivatives for the treatment of neuro-fibromatosis
展开▼
机译:二甲基氨基苯甲酰胺衍生物治疗神经纤维瘤病
展开▼
页面导航
摘要
著录项
相似文献
摘要
1. A method for the treatment or prevention of benign brain tumors, which consists in the fact that the patient is administered pyrimidylaminobenzamide derivatives of the formula (I),! ! where R1 is hydrogen, (ness.) alkyl, (ness.) alkoxy (ness.) alkyl, acyloxy (ness.) alkyl, carboxy (ness.) alkyl, (ness.) alkoxycarbonyl (ness.) alkyl or phenyl (ness. .) alkyl,! R2 is hydrogen, lower alkyl optionally substituted with one or more, same or different radicals R3, cycloalkyl, benzocycloalkyl, heterocyclyl, an aryl group or a mono- or bicyclic heteroaryl group containing 0, 1, 2 or 3 cyclic nitrogen atoms and 0 or 1 oxygen atom and 0 or 1 sulfur atom, and these groups in each case are unsubstituted or mono- or polysubstituted, and! R3 is hydroxy, (ness.) Alkoxy, acyloxy, carboxy, (ness.) Alkoxycarbonyl, carbamoyl, N-mono- or N, N-disubstituted carbamoyl, amino, mono- or disubstituted amino, cycloalkyl, heterocyclyl, an aryl group or mono - or a bicyclic heteroaryl group containing 0, 1, 2 or 3 cyclic nitrogen atoms and 0 or 1 oxygen atom and 0 or 1 sulfur atom, and these groups in each case are unsubstituted or mono- or polysubstituted, or! R1 and R2 together mean alkylene containing 4, 5 or 6 carbon atoms, optionally mono- or disubstituted by a group of lower alkyl, cycloalkyl, heterocyclyl, phenyl, hydroxy, lower alkoxy, amino, mono- or disubstituted amino, oxo, pyridyl, pyrazinyl or pyrimidinyl, or mean benzalkylene containing 4 or 5 carbon atoms, oxaalkylene containing 1 oxygen atom and 3 or 4 carbon atoms, or azaalkylene containing 1 nitrogen atom and 3 or 4 carbon atoms, and the nitrogen atom is unsubstituted or is substituted by a group (neither
展开▼
机译:1.一种治疗或预防良性脑肿瘤的方法,其特征在于,给患者施用式(I)的嘧啶基氨基苯甲酰胺衍生物! !其中R1为氢,(烷基),(烷基)烷氧基,(烷基),酰氧基(烷基),羧基(烷基),(烷基)烷氧基羰基(烷基)或苯基(烷基) 。)烷基,! R 2是氢,任选地被一个或多个相同或不同的基团取代的低级烷基R 3,环烷基,苯并环烷基,杂环基,芳基或含有0、1、2或3个环氮原子且0或0的单或双环杂芳基1个氧原子和0或1个硫原子,并且这些基团在每种情况下都是未取代的或单或多取代的,并且! R 3是羟基(正)烷氧基,酰氧基,羧基(正)烷氧羰基,氨基甲酰基,N-单或N,N-二取代的氨基甲酰基,氨基,单或二取代的氨基,环烷基,杂环基,芳基或含有0、1、2或3个环氮原子和0或1个氧原子和0或1个硫原子的单环或双环杂芳基,这些基团在每种情况下都是未取代的或单取代或多取代的,或! R 1和R 2一起是指含有4、5或6个碳原子的亚烷基,其任选地被低级烷基,环烷基,杂环基,苯基,羟基,低级烷氧基,氨基,单或二取代的氨基,氧代,吡啶基的基团单取代或二取代,吡嗪基或嘧啶基,或指的是含4个或5个碳原子的苯亚烷基,含1个氧原子和3个或4个碳原子的氧杂亚烷基或含1个氮原子和3个或4个碳原子的氮杂亚烷基,并且氮原子未被取代或被a取代组(都不
展开▼