AMINOACYLIC DERIVATIVES AND MEDICINES FOR THE TREATMENT OF THROMBOEMBOLIC DISEASES

摘要

1. The compound of formula (I):! ! in which R1 is hydrogen or alkyl with 1-4 carbon atoms, which may be substituted with hydroxy or alkoxy with 1-4 carbon atoms,! R2 means hydrogen or alkyl with 1-4 carbon atoms and! L means an alkanediyl group with 1-4 carbon atoms, one CH2 group in which can be replaced by an oxygen atom or a group of the formula:! ,! or ! in which * means the junction with the nitrogen atom,! R3 means a side group of a natural α-amino acid or its homologs or isomers, or! R3 is connected to R1, together with which it forms a (CH2) 3- or (CH2) 4-group,! R4 is hydrogen or methyl! R5 means alkyl with 1-4 carbon atoms, and! R6 means hydrogen or alkyl with 1-4 carbon atoms,! as well as its salts, solvates and solvates of salts. ! 2. The compound of formula (I) according to claim 1, in which! R1 means hydrogen or alkyl with 1-4 carbon atoms,! R2 means hydrogen and! L means an alkanediyl group with 2-4 carbon atoms or a group of the formula:! , or ! in which * means the junction with the nitrogen atom,! R3 is hydrogen, methyl, propan-2-yl, propan-1-yl, imidazol-4-ylmethyl, hydroxymethyl, 1-hydroxyethyl, carbamoylmethyl, 2-carbamoylethyl, 4-aminobutan-1-yl, 3-amino-propan- 1-yl or 3-guanidinopropan-1-yl, or! R3 is connected to R1, together with which it forms a (CH2) 3- or (CH2) 4-group,! R4 is hydrogen or methyl! R5 means methyl and! R6 is hydrogen or methyl! as well as its salts, solvates and solvates of salts. ! 3. The compound of formula (I) according to claim 1 or 2, in which! R1 is hydrogen, methyl or n-butyl,! R2 means hydrogen and! L is a CH2CH2 group or a group of the formula:! or ! in which * means the junction with the nitrogen atom,! R3 is hydrogen, methyl, propan-2-yl, propan-1-yl, im