METHODS AND COMPOSITIONS FOR THE TREATMENT OF HYPERALGESIA

摘要

1. A method of treating hyperalgesia in a subject, comprising administering to the subject a pharmaceutical composition that comprises an effective amount of an TRPA1 ion channel antagonist, wherein the TRPA1 antagonist specifically blocks TRPA1 activation, thereby eliminating or inhibiting harmful chemical, thermal and mechanical sensitivity in the subject. ! 2. The method according to claim 1, in which the TRPA1 antagonist does not block the activation of one or more other thermo-TCR channels selected from the group consisting of TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8. ! 3. The method according to claim 1, wherein the TRPA1 ion channel antagonist is (Z) -4- (4-chlorofinil) -3-methylbut-3-en-2-oxime. ! 4. The method according to claim 1, wherein the TRPA1 antagonist is N, N'-bis- (2-hydroxybenzyl) -2,5-diamino-2,5-dimethylhexane. ! 5. The method according to claim 1, wherein the TRPA1 antagonist is a TRPA1 antagonistic antibody. ! 6. The method according to claim 1, in which the subject has an inflammatory condition or neuropathic pain. ! 7. The method according to claim 1, in which the subject of the disorder is mechanical or thermal hyperalgesia. ! 8. The method according to claim 1, in which the subject is a person. ! 9. The method according to claim 1, further comprising administering to the subject a second pain relieving agent. ! 10. The method of claim 9, wherein the second pain relieving agent is a painkiller selected from the group consisting of acetaminophen, ibuprofen, and indomethacin, as well as opioids. ! 11. The method according to claim 9, in which the second agent that reduces pain is an analgesic agent selected from the group comprising morphine and moxonidine. ! 12. A method for identifying an agent that suppresses or eliminates harmful mechanical sensitivity, which includes (a) contacting a study