COMPOSITIONS, INCLUDING TAGASEROD IN SEPARATELY OR IN COMBINATION WITH A PROTON PUMP INHIBITOR, FOR TREATMENT OR PREVENTION OF GASTRONOMAL INJURIES

摘要

1. A pharmaceutical composition comprising tegaserod and a proton pump inhibitor. ! 2. The pharmaceutical composition according to claim 1, wherein the proton pump inhibitor is selected from the group consisting of omeprazole, esomeprazole, lanzoprazole, rabeprazole, pantoprazole and leminoprazole. ! 3. The pharmaceutical composition according to claim 1, where the proton pump inhibitor is omeprazole. ! 4. A method of treating or preventing damage to the gastrointestinal tract in a subject in need of such treatment, comprising administering to the subject an effective amount of tegaserod. !5. The method according to claim 4, where damage to the gastrointestinal tract is induced by the administration of a non-steroidal anti-inflammatory drug (NSAID). ! 6. The method according to claim 4, where tegaserod is administered in combination with a proton pump inhibitor. ! 7. The method according to claim 6, where the proton pump inhibitor is selected from the group consisting of omeprazole, esomeprazole, lanzoprazole, rabeprazole, pantoprazole and leminoprazole. ! 8. The method according to claim 6, where the proton pump inhibitor is omeprazole. ! 9. The method according to claim 6, where tegaserod is first introduced, and then a proton pump inhibitor. ! 10. The method according to claim 6, where the proton pump inhibitor is first introduced, and then tegaserod. ! 11. The method according to claim 6, where tegaserod and a proton pump inhibitor are administered simultaneously. ! 12. The use according to claim 4, where the damage to the gastrointestinal tract is selected from the group including damage to the mucous membrane, dysfunction of the muscles of the gastrointestinal tract, gastritis, peptic erosion, ulcers and pathological changes in the gastrointestinal tract. ! 13. A method for treating pain and / or inflammation in a subject, comprising administering to a subject in need of such treatment a therapeutic