PHARMACEUTICAL COMPOSITION FOR TREATMENT OF VIRAL INFECTIONS AND TUMOR DISEASES BY INHIBITION OF PROTEIN LAYING AND PROTEIN DECOMPOSITION

摘要

1. The use of a pharmaceutical composition for the preparation of a treatment for viral infections containing, as active components, at least one ubiquitin-proteasome system inhibitor and one protein folding enzyme inhibitor. ! 2. The use according to claim 1, characterized in that in the case of an inhibitor of protein folding enzymes we are talking about at least one inhibitor of cell chaperones or at least one chemical substance that directly affects the folding of proteins (chemical Chaperone). ! 3. The use according to claim 2, characterized in that substances that are used as inhibitors of cellular chaperones or chemical anti-chaperones! a) inhibit the folding and proteolytic maturation of viral proteins, regulate or otherwise act, and thereby inhibit the release and replication of viruses, especially infectious agents, such as AIDS, hepatitis, hemorrhagic fever, SARS (acute respiratory syndrome), smallpox, measles, poliomyelitis caused by herpesvirus infection or flu! or ! b) inhibit the reproduction of degenerated cells, in particular tumor cells, causing them to enter programmed cell death due to the accumulation of improperly laid proteins. ! 4. The use according to claim 2, characterized in that the cell chaperones or chemical anti-chaperones that are used as inhibitors are! a) in natural form isolated from microorganisms or other natural sources, or! b) made by chemical modifications from natural substances, or! c) obtained completely synthetically, or! d) synthesized in vivo by methods�