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A composition comprising human recombinant interferon alpha-2B, and prolonged drug for veterinary medicine on its basis, has antiviral and immunomodulatory effects

机译:包含人重组干扰素α-2B和以其为基础的兽医用延长药物的组合物具有抗病毒和免疫调节作用

摘要

1. A composition having antiviral and immunomodulating action, containing hydrophobic complex of the two polymers with interferon - dextran and methylcellulose. ! 2. A composition according to claim 1, characterized in that the dextran with a molecular weight of 30,000 or 60,000, or a mixture thereof. ! 3. A composition according to claim 1, characterized in that this composition further comprises a buffer salt to stabilize pH in the region 5.0-7.5. ! 4. A medicament comprising a composition according to any one of claims 1-3. ! 5. A medicament according to claim 4, characterized in that said means is a sterile solution for injection. ! 6. A medicament according to claim 5, characterized in that the following ratio of components per ml: human recombinant interferon alfa-2b 10-200 million. ME dextran methylcellulose 5-10 mg 1-20 mg sodium phosphate buffer 50 mM Sodium chloride 8.7 mg Potassium chloride 0.3 mg hydrochloric acid or sodium hydroxide to pH 5,0- 7.5 water for injections to 1 ml! 7. A medicament according to claim 4, characterized in that said means is a sterile lyophilisate for solution for injection. ! 8. A medicament according to claim 7, characterized in that the following ratio of components per ml of solution for injection: human recombinant interferon alfa-2b 10-200 million. ME dextran methylcellulose 5-10 mg 1-20 mg sodium phosphate buffer 50 mM Sodium chloride 8.7 mg Potassium chloride 0.3 mg hydrochloric acid or sodium hydroxide to pH 5,0- 7.5
机译:1.具有抗病毒和免疫调节作用的组合物,其包含两种聚合物与干扰素-葡聚糖和甲基纤维素的疏水复合物。 ! 2.根据权利要求1的组合物,其特征在于分子量为30,000或60,000的右旋糖酐或其混合物。 ! 3.根据权利要求1的组合物,其特征在于该组合物还包含缓冲盐以将pH稳定在5.0-7.5范围内。 ! 4.药物,其包含根据权利要求1-3中任一项的组合物。 ! 5.根据权利要求4所述的药物,其特征在于,所述装置是用于注射的无菌溶液。 ! 6.根据权利要求5的药物,其特征在于每毫升以下组分的比例:人重组干扰素α-2b为10-200百万。 ME葡聚糖甲基纤维素5-10 mg 1-20 mg磷酸钠缓冲液50 mM氯化钠8.7 mg氯化钾0.3 mg盐酸或氢氧化钠至pH 5.0至7.5的注射用水至1 ml! 7.根据权利要求4所述的药物,其特征在于,所述装置是用于注射溶液的无菌冻干物。 ! 8.根据权利要求7所述的药物,其特征在于,每毫升注射溶液中以下组分的比例为:人重组干扰素α-2b10-200百万。 ME葡聚糖甲基纤维素5-10 mg 1-20 mg磷酸钠缓冲液50 mM氯化钠8.7 mg氯化钾0.3 mg盐酸或氢氧化钠至pH 5.0-7.5

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