METHOD FOR PRODUCING RADIOACTIVE iodine radiolabeled AFP AND METHOD OF ITS APPLICATION FOR CANCER DIAGNOSIS

摘要

1. A process for preparing the radioactive iodine labeled with radionuclides AFP, comprising obtaining a solution of alpha-fetoprotein, placed in a vial, wherein the vial was washed with radioactive iodine-123, iodine-125 (125I-AFP) or iodine-131 phosphate buffered solution, which is then introduced into the vial with alpha-fetoprotein, yielding a mixture of the iodide and an alpha-fetoprotein, which is added chloramine-B solution in phosphate buffered saline, and then the resulting mixture was stirred for 2-5 seconds and make it to sodium sulfite stay application extension reaction with stirring for 50-70 s, and then making human serum albumin in a phosphate buffer solution and the resulting mixture was applied on a Sephadex and then combining fractions containing radioactive protein. ! 2. A method for diagnosing malignancy based on the introduction of radioactive drug intravenously to a patient, whereupon scintigraphy for visualization of malignant tumors, characterized in that, as the radioactive source used radiolabeled with radionuclides iodine-123, iodine-125 or iodine-131 alpha fetoprotein in the form of aqueous-salt solution containing human serum albumin, and scintigraphy produced in a period of from 1 to 5 hours after administration to a patient the radiolabeled radion klidami iodine-123, iodine-125 or iodine-131 AFP.