TREATMENT OR PREVENTION OF DEVELOPMENT OF MALIGNANT TUMORS OVER EXPRESSING REG4 OR KIAA0101

摘要

1. A method of treating or preventing the development of pancreatic cancer in a patient, comprising administering to said patient a composition comprising at least one small interfering RNA (siRNA) that inhibits the expression of REG4 or KIAA0101. ! 2. The method of claim 1, wherein said siRNA contains a sense nucleic acid sequence and an antisense nucleic acid sequence that specifically hybridizes to a REG4 or KIAA0101 sequence. ! 3. The method according to claim 1, where the malignant tumor that needs to be cured is selected from the group consisting of pancreatic cancer, prostate cancer, breast cancer and bladder cancer. ! 4. The method according to claim 3, where the pancreatic cancer is a ductal pancreatic adenocarcinoma (PDAC). ! 5. The method according to claim 1, where siRNA inhibits the expression of REG4, and the malignant tumor that needs to be cured is a PDAC. ! 6. The method according to claim 1, where siRNA inhibits the expression of KIAA0101, and the malignant tumor that needs to be cured is pancreatic cancer, prostate cancer, breast cancer and bladder cancer. ! 7. The method according to claim 2, where the specified siRNA contains a ribonucleotide sequence corresponding to the sequence of SEQ ID NO: 5 or SEQ ID NO: 32 as the target sequence. ! 8. The method according to claim 7, where the specified siRNA has the general formula 5 '- [A] - [B] - [A'] - 3 ', where [A] is a ribonucleotide sequence corresponding to the nucleotide sequence of SEQ ID NO: 5 or SEQ ID NO: 32,! [B] is a ribonucleotide loop sequence consisting of 3-23 nucleotides, and! [A '] submission