METHOD OF PRODUCING LIQUID COMPOSITION, CONTAINING HYPERPOLARISED ¹³C-PYRUVATE, COMPOSITION CONTAINING HYPERPOLARISED ¹³C-PYRUVATE (VERSIONS), USE THEREOF (VERSIONS), RADICAL AND USE THEREOF

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to a method of producing a liquid composition which contains hyperpolarised ¹³C-pyruvate, involving: a) formation of a liquid mixture containing a radical of formula (I) , where M is hydrogen or one equivalent cation; and R1, which are identical or different, each represents hydroxylated and/or alkoxolated C₁-C₄-hydrocarbon group with a straight or branched chain, ¹³C-pyroracemic acid and/or ¹³C-pyruvate, and freezing this mixture; b) increasing polarisation of ¹³C nuclei of pyroracemic acid and/or pyruvate in this mixture through dynamic nuclear polarisation c) addition of a physiologically transferable buffer, which provides for pH in the range from 7 to 8, and a base to the frozen mixture for its dissolution and for converting ¹³C-pyroracemic acid to ¹³C-pyruvate, obtaining a liquid composition or, when at stage (a) only ¹³C-pyruvate is used, addition of a buffer to the frozen mixture for its dissolution, obtaining a liquid composition; and d) possible removal of the radical and/or its reaction products from the liquid composition. The invention also relates to use of such a composition and to a radical of formula (I).;EFFECT: obtaining a composition for use as MP of a visualising agent.;22 cl, 2 dwg, 5 ex