POLYNUCLEOTIDE CODING ACYLTRANSFERASE THAT RESPONDS FOR MODIFICATION OF PLATENOLID IN POSITION 3 (VERSIONS), POLYPEPTIDE THAT REPRESENTS ACYLTRANSFERASE, WHICH IS RESPONSIBLE FOR MODIFICATION OF PLATENOLID IN POSITION 3 (VERSIONS), BACTERIAL EXPRESSION VECTOR (VERSIONS), BACTERIAL EXPRESSION SYSTEM, BACTERIAL HOST CELL, METHOD FOR PRODUCTION OF POLYPEPTIDE, STRAIN STREPTOMYCES AMBOFACIENS, APPLICATION OF POLYNUCLEOTIDE (VERSIONS), CELL OF BACTERIUM STREPTOMYCES AMBOFACIENS, HOST CELL STREPTOMYCES AMBOFACIENS AND METHOD OF POLYPEPTIDE PRODUCTION

摘要

FIELD: biotechnologies.;SUBSTANCE: invention is related to the field of biotechnology, specifically, to separation and identification of new genes of spiramycins biosynthesis track and to new polypeptides, which participate in this biosynthesis, and may be used to produce acyltransferase, which is responsible for modification of platenolid in position 3. Polynucleotide coding acyltransferase, which is responsible for modification of platenolid in position 3, cells of bacterium Streptomyces type are transformed, and strain-producer of end polypeptide is made.;EFFECT: increased extent of production and purity of produced spiramycin.;26 cl, 41 dwg, 44 tbl, 31 ex