PEPTIDE HAVING GROWTH-STIMULATING FACTOR OF HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR

摘要

FIELD: chemistry; biochemistry.;SUBSTANCE: invention relates to bioengineering and specifically to obtaining biologically active substances of peptide nature, which have growth-stimulating factor of the human granulocyte colon-stimulating factor and can be used in medicine. An oligopeptide of general formula I A-X1-X2-X3-X4-B (I) is obtained through in silico construction, where A is Boc - tert-butyloxycarbonyl or Ac -acetyl; X1 is E, or D, or L, or P, or S; X2 is N, or Q, or A, or G; X3 is G, or N, or V, or (β-A) - β-alanine; X4 is K or is absent and B is OMe - methyl.;EFFECT: invention enables obtaining an oligopeptide with growth-stimulating activity of the granulocyte colon-stimulating factor and which is capable of stimulating stem cell differentiation in vitro in the direction of epithelial progenitors and expand the range of effective therapeutic agents for treating diseases accompanied by myelosuppression and infectious complications.;4 dwg, 2 ex