POLYPEPTIDE WITH GROWTH HORMONE RECEPTOR AGONIST PROPERTIES, NUCLEIC ACID CODING SAID POLYPEPTIDE, EXPRESSION VECTOR THEREOF AND CELL PRODUCING SAID POLYPEPTIDE

摘要

FIELD: chemistry; biochemistry.;SUBSTANCE: invention relates to genetic and protein engineering and can be used in biomedical industry. A genetic make up is proposed, which codes a peptide in which two domains bonding the growth hormone (GH) receptor are bonded into a tandem by a "semirigid" or "rigid" linker, which consists of at least 1-4 copies of the A(EAAAK)A amino acid sequence.;EFFECT: as a result of expression of the nucleotide sequence coding the said tandem, GH-linker-GH polypeptides are obtained, which exhibit growth hormone receptor agonist properties, which determine the possibility of their use in medicinal agents for treating diseases related to the need to administer the growth hormone.;10 cl, 31 dwg, 5 ex