METHOD FOR PREPARING HEPARIN WITH LOW MOLECULAR WEIGHT AND ANTICOAGULANT ACTIVITY

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: there is offered a method for preparing low-molecular heparins by enzymatic degradation. For enzymatic depolymerisation, immobilised lysozyme is used.;EFFECT: prepared low-molecular heparin shows higher inhibitor activity with respect to blood coagulation factor Xa and lower inhibitor activity with respect to thrombin in comparison with initial heparin.;2 tbl, 3 ex