METHOD OF OBTAINING STIMULATED DENDRITE CELLS FOR INDUCTION OF IMMUNE RESPONSE AGAINST HUMAN TUBERCULOSIS

摘要

FIELD: medicine.;SUBSTANCE: invention relates to biotechnology and can be used in treatment of diseases, namely oncologic ones. Method is based on sampling from patient immature dendrite cells, their cultivation ex vivo for maturing and formation of allostimulating activity. Cells are additionally collected with antigen and are introduced to the same patient for formation of adaptive immunity. During cultivation ex vivo of immature dendrite cells fragmented allogenic double-stranded genomic DNA with fragments with size 200-6000 bp is introduced into culture medium in amount 5 mcg/ml of medium.;EFFECT: invention allows to extend field of obtained product application with increase of general immune state of patients.