Use of indole-3-carboxylic acid esters for the inhibition of microsomal prostaglandin E2 synthase

摘要

The present invention relates to the use of indole-3-carboxylic acid esters and their derivatives for the inhibition of inducible microsomal prostaglandin E2 synthase-1 and / or for the inhibition of 5-lipoxygenase. In particular, the invention relates to the use of derivatives of 3-carboxy-aryl [g] indole, especially of 2-aryl and 2-arylalkyl-aryl [g] indole-3-carboxylic acid esters and their structural derivatives for the inhibition of inducible microsomal prostaglandin E2 synthase-1 and / or for the inhibition of 5-lipoxygenase. The invention further relates to the use of indole-3-carboxylic acid esters for the preparation of a medicament for the treatment of PGE2- and / or 5-LO-mediated diseases and pathological conditions, in particular of inflammatory chronic inflammations such as rheumatoid arthritis, osteoarthritis, diseases of the cardiovascular system, Asthma, allergic rhinitis, multiple sclerosis, inflammatory skin diseases, osteoporosis and cancer, pain and fever in which PGE2 and / or 5-LO products play a role.