Differentiation of enantiomers with the aid of the broadband femtoseconds - circular dichroism - mass spectrometry

摘要

The present invention provides a device and a method for the differentiation of enantiomers with the aid of the broadband femtoseconds - circular dichroism - laser ionization - mass spectrometry ready. In this case, a fs - a laser system is used in which the laser pulse duration (τ) of less than or equal to 200 fs, based on a band-limited pulse, and the central wavelength (λ) in the range from 200 nm to 1100 nm. The spectral bandwidth of the laser pulses is selected from strip widths of less than or equal to 40 nm and such greater than 40 nm. The laser pulses are circularly polarized, wherein between the right - and left-handed circularly polarized light can be changed.The circularly polarized fs - laser pulses are directly to the ionization is used, wherein the light - material - interaction enantiomers is specific. Thus it is no separation of substance mixtures necessary. The ionization of a certain analytes of suitable wavelength, in no case be known in advance: in the case of strip widths of less than or equal to 40 nm, the wavelength varies, in order to determine the appropriate wavelength. In the case of bandwidths greater than 40 nm, for the respective molecule contain matching wavelength intrinsically in the spectrum. The sample to be investigated, and an achiral reference substance are simultaneously in the time-of-flight mass spectrometer is examined for both circular polarizations. In the case of a given ionization shafts length and polarization of the laser pulse, each in this way ..