depsipetid and congeners thereof for use as immunosuppressants for prevention and treatment of abstossreaktionen following transplantation, and the induction of apoptosis in activated cd4or cd8 t cells

摘要

Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as immunosuppressants for treating an infections disease, an autoimmune disease, allergic reactions or a hyperproliferative skin disease.