process for production of methionine fermentativen using recombinant coryneformer bacteria

摘要

Producing L-amino acids (I) by fermentation of recombinant microorganisms (A), preferably coryneform bacteria, that take up less methionine than starting organisms (or none) from the surrounding medium. In (A) one or more of the genes yaeC, abc and yaeE, encoding the MetD2 methionine-uptake system, is/are weakened, switched off or expressed at reduced level. Independent claims are also included for: (1) recombinant (A) in which at least one of the specified genes has been weakened, switched off or is expressed at reduced level; and (2) vector that is non-replicable in Corynebacterium glutamicum and includes a fragment of at least 15 consecutive nucleotides from the sequences of at least one of the specified genes.