New phenyl-alkyl-piperazine compounds, are tumor necrosis factor-alpha modulators, useful for treating e.g. joint inflammation, atherosclerosis, cystic fibrosis, asthma, ulcerative colitis, osteoporosis and amyotrophic lateral sclerosis

摘要

Phenyl-alkyl-piperazine compounds (I) and their additional salts and acids are new. Phenyl-alkyl-piperazine compounds of formula (I) and their additional salts and acids are new. R1, R2 : H, halo, 1-5C (halo)alkyl, 1-2C perfluoroalkyl, 1-5C alkoxy or 1-2C perfluoroalkoxy; R3 : 1-5C alkyl (where piperazine is bound by the ethyl group in position 3 on the phenyl group); and A : (=)CH or (=)N. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Analgesic; Immunomodulator; Antiarteriosclerotic; Antiasthmatic; Antiarthritic; Antirheumatic; Osteopathic; CNS-Gen.; Respiratory-Gen.; Antigout; Cytostatic; Antibacterial; Antiinflammatory; Gastrointestinal-Gen.; Antiulcer; Neuroprotective; Antiparkinsonian; Dermatological; Cardiant; Vasotropic; Antimalarial; Antileprotic; Virucide. MECHANISM OF ACTION : Tumor necrosis factor-alpha modulator.