Open implant having osteogenic composition comprising osteogenic growth factor, soluble divalent cation salt and organic support, useful e.g. to fill bone defects, to make spinal fusions, or to treat absence of fracture healing

摘要

Open implant constituted of an osteogenic composition comprising at least an osteogenic growth factor, a soluble divalent cation salt, and an organic support, where the organic support does not comprise demineralized bone matrix, is claimed. An independent claim is included for a process for preparation of the implant comprising first placing a solution comprising the osteogenic growth factor, second placing the organic matrix and/or polymer forming the hydrogel, first adding the solution containing the growth factor to the organic matrix and/or the hydrogel, and optionally homogenizing the mixture, second adding a solution of a soluble divalent cation salt to the obtained implant, and optionally processing freeze-drying of the obtained implant. ACTIVITY : Osteopathic. MECHANISM OF ACTION : None given.