VAGINALLY ADMINISTERED ANTI-DYSRHYTHMIC AGENTS FOR TREATING PELVIC PAIN AND INFERTILITY

摘要

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for relieving pelvic pain or infertility associated with uterine dysrhythmia.SOLUTION: The composition includes a locally-administered anti-dysrhythmic treating agent and a bioadhesive extended-release carrier and may be delivered in an extended release formulation that includes a bioadhesive, water-swellable, water-insoluble, cross-linked polycarboxylic acid polymer, such as polycarbophil. The treating agent may be a local anesthetic, such as lidocaine. The invention also relates to a method of treating or preventing pelvic pain, or treating or improving infertility, by inserting a mixture of an anti-dysrhythmic treating agent and a bioadhesive carrier into the vagina of the patient to be treated.