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NEURAMINIC ACID DERIVATIVE, SIALIDASE ACTIVITY INHIBITOR AND ANTI-INFLUENZA MEDICINE

机译:神经胺酸衍生物,唾液酸酶活性抑制剂和抗流感药物

摘要

PPROBLEM TO BE SOLVED: To provide a neuraminic acid derivative which selectively inhibits the sialidase activity of viruses and hardly inhibits human sialidase activity, to provide a sialidase activity inhibitor, and to provide an anti-influenza medicine. PSOLUTION: The neuraminic acid derivative comprises a compound represented by chemical formula (1) (RSB1/SBand RSB2/SBare each H, a 1 to 8C optionally branched alkyl, or a 1 to 8C optionally branched cycloalkyl; RSB3/SBis H or F), or pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof. PCOPYRIGHT: (C)2011,JPO&INPIT
机译:<解决的问题:提供一种神经氨酸衍生物,其选择性抑制病毒的唾液酸酶活性并且几乎不抑制人唾液酸酶活性,提供唾液酸酶活性抑制剂,并提供抗流感药物。

解决方案:神经氨酸衍生物包含化学式(1)表示的化合物(R 1 和R 2 分别为H,1至8C可选地分支的烷基,或1至8C任选分支的环烷基; R SB 3是H或F),或其药学上可接受的盐,水合物,溶剂化物或前药。

版权:(C)2011,日本特许厅&INPIT

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