COMPOSITION HAVING BOTH DIPEPTIDYL PEPTIDASE IV INHIBITORY ACTIVITY IN BLOOD AND SECRETION PROMOTION ACTIVITY OF GLUCAGON-LIKE PEPTIDE-1

摘要

PROBLEM TO BE SOLVED: To provide a material effective for preventing and treating diabetes and obesity by increasing endogenous GLP-1.;SOLUTION: Glucagon-like peptide-1 (GLP-1) being a digestive tract hormone is known to have an antidiabetic effect, however, only promotion of secretion of GLP-1 exhibits an insufficient effect, inhibition of decomposition as well as promotion of secretion is effective, concretely, a remarkable effect is obtained by inhibiting dipeptidyl peptidase-IV(DPP-IV) in blood. The preventive or therapeutic agent for diabetes or obesity comprises corn protein Zein hydrolyzate (ZeinH) having both secretion promotion action on GLP-1 and inhibitory action on DPP-IV or its amino acid sequence Leu-Pro-Phe as an active ingredient.;COPYRIGHT: (C)2011,JPO&INPIT