首页> 外国专利> Method for improving cardiovascular risk factor of COX inhibitor

Method for improving cardiovascular risk factor of COX inhibitor

机译:改善cox抑制剂心血管危险因素的方法

摘要

A method of reducing the increased risk of cardiovascular events attendant with the use of COX or selective COX-2 inhibitors including restoring disrupted cholesterol metabolic function engendered by the use of the COX or selective COX-2 inhibitors and reducing the production of foam cells caused thereby. The disrupted cholesterol metabolic function is restored and the production of foam cells is reduced by the step of administering an adenosine A2A receptor agonist having a threshold level of activity of 0.1 muM to a patient using the COX or COX-2 inhibitor. The adenosine A2A receptor agonist is administered orally in amounts sufficient to saturate the A2A receptor and at time intervals sufficient to maintain the restored cholesterol metabolic function.
机译:一种减少使用COX或选择性COX-2抑制剂伴随发生心血管事件的风险增加的方法,包括恢复因使用COX或选择性COX-2抑制剂而引起的胆固醇代谢功能紊乱并减少由此引起的泡沫细胞的产生。通过使用COX或COX-2抑制剂向患者施用具有0.1μM的阈值活性水平的腺苷A2A受体激动剂的步骤,恢复了破坏的胆固醇代谢功能并减少了泡沫细胞的产生。腺苷A2A受体激动剂的口服剂量应足以使A2A受体饱和,并以足以维持恢复的胆固醇代谢功能的时间间隔进行。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号