Expression purification of influenza virus PA and crystal structure of PA N-terminal and PA C-terminal and PB1 N-terminal polypeptide complex

摘要

Provided are the expression method of influenza virus polymerase PAc-PB1 N N complex, the co-crystallization method of the complex and the three-dimendional structure of the crystal of PAc-PB1 N complex. Also provided are the compounds binding to the influenza virus polymerase PAc and the expression method of influenza virus polymerase PA N . The three-dimensional structure of the crystal of PAc-PB1 N complex can be used for screening and designing the drug for the treatment of influenza.