Using siRNA to achieve down-regulation of the endogenous gene in combination with the use of sense constructs to achieve expression of the desired polynucleotide

摘要

To express in a host proteins combined use of siRNA targeting the endogenous gene for the knock down or knock out expression of the endogenous gene in the host, and is encoded by a polynucleotide, the invention is a host relates to send out a polynucleotide encoding a gene delivery vehicle / expression vector.