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Veterinary formulation for administration of water-insoluble drugs through a water distribution system to target animals

机译:通过水分配系统向目标动物施用水不溶性药物的兽用制剂

摘要

This invention concerns a method for the preparation of a suspoemulsion formulation, which can be easily produced on an industrial scale and which allows the reproducible and effective administration of one or more water-insoluble veterinary drugs through water distribution systems. The water-insoluble veterinary drug, in finely ground form, is dispersed in a water immiscible liquid, followed by homogenization of this system into a water phase. To facilitate the preparation of a stable formulation, one or more stabilizing agents such as emulsifiers, thickeners, anti-oxidants and anti-microbials can be used. The resulting suspoemulsion shows excellent long term storage stability and a good in use stability after dilution in a vessel and during all handling and transport in the water distribution system.
机译:本发明涉及一种制备悬浮乳剂的方法,该悬浮乳剂可以容易地以工业规模生产,并允许通过水分配系统可再现和有效地施用一种或多种水不溶性兽药。将精细研磨形式的水不溶性兽药分散在与水不混溶的液体中,然后将该系统均质化为水相。为了促进稳定制剂的制备,可以使用一种或多种稳定剂,例如乳化剂,增稠剂,抗氧化剂和抗微生物剂。所得的悬浮乳液在容器中稀释后以及在水分配系统中的所有处理和运输过程中,均显示出优异的长期储存稳定性和良好的使用稳定性。

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