Computer system and method for calculating pharmacokinetic behavior of chemicals in insects

摘要

System, to compute the pharmacokinetic behavior of a chemical substance in insects, uses a simulation model with a database with a physiological base for an insect, to predict the concentration-time progress in various compartments of the insect with at least one parameter dependent on the substance with physiological constants. The parameter is the permeability of the substance and the effective compartment surface. The computer system (100), to compute the pharmacokinetic behavior of a chemical substance in insects, uses a simulation model (102) with a database (108). The simulation model has a physiological base for an insect, to predict the concentration-time progress in various compartments of the insect with at least one parameter (106) dependent on the substance with physiological constants (104). The prediction module (110) predicts at least one parameter based on a physicochemical characteristic of the substance. The parameter is the permeability of the substance and the effective compartment surface.