Compositions that specifically bind to colorectal cancer cells and methods of use thereof

摘要

PCT No. PCT/US94/12232 Sec. 371 Date Apr. 26, 1996 Sec. 102(e) Date Apr. 26, 1996 PCT Filed Oct. 26, 1994 PCT Pub. No. WO95/11694 PCT Pub. Date May 4, 1995Conjugated compounds which comprise an ST receptor binding moiety and a radiostable active moiety are disclosed. Pharmaceutical compositions comprising conjugated compound which comprises an ST receptor binding moiety and a radiostable active moiety or an ST receptor binding moiety and a radioactive active moiety are disclosed. Methods of treating an individual suspected of suffering from metastasized colorectal cancer are disclosed. Methods of radioimaging metastasized colorectal cancer cells are disclosed. In vitro methods, kits and reagents are disclosed for determining whether or not an individual has metastasized colorectal cancer cells, for determining whether tumor cells are colorectal in origin and for analyzing tissue samples from the colon tissue to evaluate the extent of metastasis of colorectal tumor cells.