Pyrimidinone derivatives as therapeutic agents for acute and chronic inflammation, ischemia and remodeling processes

摘要

Compounds of formula (I) and salts, hydrates and/or solvates thereof and their tautomeric forms in which A is an aryl or heteroaryl ring, each of R1, R2 and R3 are independently H or various substituents, R4, R5, R6 and R7 are various substituents and each of Y1, Y2 Y3, Y4, and Y5 are independently CH or N so that the ring contains 0, 1 or 2 nitrogen atoms. In particular, A is a phenyl ring, each of Y1-Y5 is CH and R4 is an alkoxycarbonyl residue. The compounds may be inhibitors of human leukocyte elastase (HLE, also known as human neutrophil elastase or HNE) and as such may be useful in the treatment of chronic obstructuive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.