Metabolic syndrome treatment or prevention agent, test method, test drug, and screening method for candidate compound of metabolic syndrome treatment drug

摘要

An object of the present invention is to provide a therapeutic or preventive agent for metabolic syndrome capable of improving in vivo stability. The therapeutic or prophylactic agent for metabolic syndrome comprises, as an active ingredient, the DNA according to any one of the following (a) to (d) encoding receptor activity-modifying protein (RAMP) 2, or a polypeptide encoded by this DNA contains. (A) DNA having the base sequence described in SEQ ID NO: 1 (b) DNA having a base sequence capable of hybridizing with the base sequence described in SEQ ID NO: 1 under stringent conditions (c) 1 in the amino acid sequence described in SEQ ID NO: 2 Alternatively, a DNA having a base sequence encoding an amino acid sequence in which a plurality of amino acids are substituted, deleted and / or added (d) a DNA comprising a base sequence having 90% or more homology with the base sequence described in SEQ ID NO: 1