NOVEL FLAVONOL COMPOUNDS, A BIOACTIVE EXTRACT/FRACTION FROM ULMUS WALLICHIANA AND ITS COMPOUNDS FOR PREVENTION FOR TREATMENT OF OSTEO-HEALTH RELATED DISORDERS

摘要

The present invention provides a flavonol compound and a bioactive extract/fraction from Ulmus wallichiana useful for the management or prevention or treatment of bone disorders. Said extract/fraction comprising marker compounds of general formula 2, K058: R₁═R₂═0H K012: R₁═R₂═OH, 2,3 double bond K068: R₁═R₂═H KIOOi R₁═OH, R₂═H mula 2 Wherein the marker compounds K012, K058, K068, K100 ranges 6.7-12%, 1.7-4.5%, 0.6-1.2%, 1.7-4.5% respectively in alcoholic extract and a process of extraction thereof. According to another aspect of the invention provides a pharmaceutical composition comprising the said compound. The present invention further provides a method of treating bone disorders by administering the pharmaceutical composition by oral, intravenous, subcutaneous, intra-peritoneal or intramuscular route.;