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MEASLES VIRUS FOR THE ELIMINATION OF UNWANTED CELL POPULATIONS
MEASLES VIRUS FOR THE ELIMINATION OF UNWANTED CELL POPULATIONS
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机译:消除有害细胞数量的麻疹病毒
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摘要
The present invention concerns recombinant measles virus as a therapeutic, in particular a recombinant measles virus comprising a suicide gene in its genome, a mutated viral hemagglutinin, and a specificity domain specifically recognizing a cancer antigen. Furthermore, it relates to a polynucleotide coding for such a recombinant measles virus and a vector comprising said polynucleotide. The current invention also relates to a method for the manufacture of and a medicament comprising said recombinant measles virus, as well as a method for treating a solid tumor using said recombinant measles virus.
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