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CROSS-LINKING REAGENTS FOR MOLECULAR INTERACTIONS ANALYSIS
CROSS-LINKING REAGENTS FOR MOLECULAR INTERACTIONS ANALYSIS
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机译:用于分子相互作用分析的交联试剂
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摘要
The invention describes the use of particular cross-linking reagents containing 1-hydroxybenzotriazole or 1-hydroxy-7-azabenzotriazole groups as reactive groups for cross-linking reactions of supramolecular target-ligand-complexes. The resulting cross-linked products may be directly analyzed using mass spectrometry, gel or fluorescence based technologies, X-ray crystallography, NMR or other analytical technologies. The method using High-Mass MALDI mass spectrometry provides various biological applications such as characterization of antibodies, drug discovery, and protein complex analysis including automated or higher throughput applications.
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