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EVALUATION OF 24S-HYDROXYCHOLESTEROL IN HAIR FOR METABOLIC BIOMARKER OF ALZHEIMER'S DISEASE
EVALUATION OF 24S-HYDROXYCHOLESTEROL IN HAIR FOR METABOLIC BIOMARKER OF ALZHEIMER'S DISEASE
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机译:老年性痴呆患者代谢性生物标志物中24S-羟基胆固醇的评估
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摘要
Disclosed is a method for detection of 24S-hydroxycholesterol in hair. More specifically, a trace amount of hair is hydrolyzed under basic condition and metabolites including 24S-hydroxycholesterol are purified and extracted by solid-phase extraction (SPE). Then, after derivatization of the resulting extract with trimethylsilyl (TMS), 24S-hydroxycholesterol is detected by gas chromatography-mass spectrometry (GC-MS).
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