首页> 外国专利> METHOD FOR SCREENING OF 5HT7 RECEPTOR LIGANDS BASED ON A NEW PHARMACOPHORE MODEL AND A DESCRIPTOR'S PROFILE FILTER

METHOD FOR SCREENING OF 5HT7 RECEPTOR LIGANDS BASED ON A NEW PHARMACOPHORE MODEL AND A DESCRIPTOR'S PROFILE FILTER

机译：基于新药模型和描述者特征过滤器的5HT7受体配体的筛选方法

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摘要

The present invention relates to compounds having pharmacological activity towards the 5-HT₇receptor; to a method for identifying them as 5-HT₇ligands, especially as agonists, by using a pharmacophore and a descriptor's profile filter; to pharmaceutical compositions comprising them; and to their use in therapy, in particular for the treatment and or prophylaxis of a disease in which 5-HT₇is involved, such as CNS disorders.

机译：本发明涉及对5-HT _{7 受体具有药理活性的化合物。一种通过使用药效基团和描述符的特征过滤器将它们识别为5-HT _{7 配体，特别是激动剂的方法;包含它们的药物组合物;及其在治疗中的用途，特别是用于治疗和/或预防涉及5-HT _{7 的疾病（例如中枢神经系统疾病）。}}}

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公开/公告号US2011124657A1

专利类型
公开/公告日2011-05-26

原文格式PDF
申请/专利权人 ROSALIA PASCUAL-RAMON;H. HELMUT BUSCHMANN;
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申请/专利号US200913055970
发明设计人 ROSALIA PASCUAL-RAMON;H. HELMUT BUSCHMANN;
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申请日2009-07-30
分类号A61K31/496;C40B30/02;C07D209/14;C07D401/06;C07D403/06;C07D295/096;C07D403/10;C07D295/13;C07D401/04;C07D453/02;A61K31/4045;A61K31/495;A61K31/454;A61K31/4439;A61K31/439;A61P25;A61P25/04;A61P25/20;A61P25/24;A61P25/06;A61P25/22;A61P25/18;A61P25/28;A61P9;A61P9/10;A61P9/12;A61P1;A61P29;A61P13;
国家 US
入库时间 2022-08-21 18:14:38

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