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PROCESS FOR PREPARING METHYL METHYLCARBAMATE AND ITS PURIFICATION FOR USE AS PHARMACEUTICALLY ACTIVE COMPOUND

机译:氨基甲酸甲酯的制备方法及其提纯用作药物活性化合物的方法

摘要

The present invention relates to a process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate of the formula (I); embedded image ;and to a process for purifying the crude product of the compound of the formula (I) for use as pharmaceutically active compound, where, for purification, methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate sulphinyldimethane (1:1), i.e. a compound of the formula (II), is isolated as intermediate or is generated as intermediate in this purification process, if appropriate present in a mixture.
机译:本发明涉及一种制备甲基{4,6-二氨基-2- [1-(2-氟苄基)-1H-吡唑并[3,4-b]吡啶-3-基]嘧啶-5-基}的方法。式(I)的氨基甲酸甲酯; “嵌入式图像” ;以及用于纯化用作药物活性化合物的式(I)化合物的粗产物的方法,其中用于纯化的是甲基{4,6-二氨基-2- [1-(2-氟苄基)- 1H-吡唑并[3,4-b]吡啶-3-基]嘧啶-5-基}甲基氨基甲酸酯亚磺酰基二甲烷(1:1),即式(II)的化合物,作为中间体被分离或作为中间体在如果合适,则以混合物形式存在。

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