首页> 外国专利> Ganoderma tsugae Active Substance Having Endothelial Cell-protecting and Atherosclerosis-preventing Effects, Process for Preparing the Same and Composition Containing the Same

Ganoderma tsugae Active Substance Having Endothelial Cell-protecting and Atherosclerosis-preventing Effects, Process for Preparing the Same and Composition Containing the Same

机译：具有内皮细胞保护和预防动脉粥样硬化作用的杉灵芝活性物质，其制备方法和包含该物质的组合物

页面导航

摘要
著录项
相似文献

摘要

A Ganoderma tsugae active substance, produced from Ganoderma tsugae by following steps: (1) liquid culturing Ganoderma tsugae; (2) extracting the fermentation filtrate obtained with ethanol to obtain ethanol extraction precipitate; (3) purifying the ethanol extraction precipitate obtained by gel filtration chromatography to obtain gel filtration chromatographed product; and (4) extracting the gel filtration chromatographed product obtained with acetone to obtain the supernatant as the desired Ganoderma tsugae active substance. The invention provides further a composition comprising Ganoderma tsugae active substance produced by the above-described steps, said composition is useful for inducing or increasing the quantity of intranuclear transcription factor Nrf2, promoting the activities of antioxidant response element promoter (ARE promoter) and Thioredoxin reductases promoter (TrxR promoter), and inducing expressions of Heme oxygenase-1 (HO-1) and Thioredoxin reductases (TrxR), so as to achieve effects of protecting cell or preventing atherosclerosis.

机译：通过以下步骤从灵芝生产的灵芝活性物质：（1）液体培养灵芝; （2）用乙醇提取得到的发酵滤液，得到乙醇提取沉淀。（3）纯化通过凝胶过滤色谱法得到的乙醇提取沉淀，得到凝胶过滤色谱法产物; （4）提取用丙酮得到的凝胶过滤层析产物，得到上清液，其为所需的灵芝活性成分。本发明还提供了包含通过上述步骤生产的灵芝灵芝活性物质的组合物，所述组合物可用于诱导或增加核内转录因子Nrf2的量，促进抗氧化反应元件启动子的活性。（ARE启动子）和硫氧还蛋白还原酶启动子（TrxR启动子），并诱导血红素加氧酶-1（HO-1）和硫氧还蛋白还原酶（TrxR）的表达，从而达到保护细胞或预防动脉粥样硬化的作用。 展开▼

著录项

公开/公告号US2010322960A1

专利类型

公开/公告日2010-12-23

原文格式PDF

申请/专利权人 YU-SHAN WEI;CHIA-WEN HSIEH;BEING-SUN WUNG;
展开▼

申请/专利号US20090489336

发明设计人 YU-SHAN WEI;CHIA-WEN HSIEH;BEING-SUN WUNG;
展开▼

申请日2009-06-22

分类号A61K36/06;A61P9/10;

国家 US

入库时间 2022-08-21 18:13:28

相似文献

专利

外文文献

中文文献

1. 一种具有保肝功效的灵芝活性物质与人源干细胞活性因子的组合物及其制备方法 [P] . 中国专利： CN107714740A . 2018-02-23

2. 一种具有抗肿瘤功效的灵芝生物活性物质与人源干细胞活性因子组合物的制备方法 [P] . 中国专利： CN107744532A . 2018-03-02

3. Ganoderma tsugae active substance having endothelial cell-protecting and atherosclerosis-preventing effects, process for preparing the same and composition containing the same [P] . 欧洲知识产权局专利： EP2266589A1 . 2010-12-29

机译：具有保护内皮细胞和预防动脉粥样硬化作用的灵芝杉活性物质，其制备方法和包含该物质的组合物

4. Sulfoniloxazolaminas as Therapeutic active substances, a process for their preparation, their use as Therapeutic active substances and / or prepare Pharmaceutical compositions.The pharmaceutical compositions containing them and Process for preparing these compositions dosage [P] . AR021896A1 . 2002-08-07

机译：用作治疗活性物质的磺胺恶唑酰胺类化合物，其制备方法，其作为治疗活性物质和/或制备药物组合物的用途。含有它们的药物组合物和制备这些组合物的方法的剂量

5. WATER ACTIVE SUBSTANCE COMPOSITION, PROCESS FOR PREPARING AN ACTIVE SUBSTANCE COMPOSITION, USE OF AN ACTIVE SUBSTANCE COMPOSITION, AND PROCESS FOR PROTECTION OF CELLULOSIS AGAINST MICROORGANISM INFESTATION [P] . BRPI0510188B1 . 2014-12-02

机译：水活性物质组合物，制备活性物质组合物的方法，使用活性物质组合物的方法以及防止微生物侵染的纤维素的方法

1. Effects of ensiling processes and antioxidants on fatty acid concentrations and compositions in corn silages [J] . Liying Han, He Zhou 畜牧与生物技术杂志：英文版 . 2014,第002期

2. Effects of ensiling processes and antioxidants on fatty acid concentrations and compositions in corn silages [J] . Liying Han, He Zhou 畜牧与生物技术杂志(英文版) . 2014,第002期

3. Effects of Coexisting Substances on Nitrobenzene Degradation with O3/H2O2 Process in High-Gravity Fields [J] . Zhang Shiguang, Qin Yuejiao, Zhang Dongming, 中国炼油与石油化工（英文版） . 2016,第004期

4. Effects of extra-cellular polymeric substances on organic pollutants biodegradation kinetics for A-step of adsorption-biodegradation process [J] . 中南大学学报（英文版） . 2006,第003期

5. Antitumor Active Protein-containing Glycans from the Body of Ganoderma tsugae [J] . LIU Ying, LI Yue-fei, ZHENG Ke-yan, 高等学校化学研究（英文版） . 2012,第003期

6. Isolating a Cytoprotective Compound from Ganoderma tsugae: Effects on Induction of Nrf-2-Related Genes in Endothelial Cells [J] . Yu-Shan Wei, Being-Sun Wung, Yuan-Chun Lin Bioscience, Biotechnology, and Biochemistry . 2009,第8期

7. Chemical Composition and Medicinal Value of the New Ganoderma tsugae var. jannieae CBS-120304 Medicinal Higher Basidiomycete Mushroom [J] . Chan Jannie Siew Lee, Asatiani Mikheil D., Sharvit Lital, International Journal of Medicinal Mushrooms . 2015,第8期

8. Quantitative Effects of Oxygen Supply on Mycelia Growth and Extracellular Polysaccharide of Ganoderma tsugae [C] . Nukrob Narkprasom, Tzou-Chi Huang, Yuan-Kuang Guu International Conference on Advanced Design and Manufacturing Engineering . 2012

9. Frequency Effects on ESL Compositional Multi-Word Sequence Processing. [D] . Supasiraprapa, Sarut. 2017

10. Triterpenoids and Polysaccharide Fractions of Ganoderma tsugae Exert Different Effects on Antiallergic Activities [O] . Miaw-Ling Chen, Chia-Chien Hsieh, Bor-Luen Chiang, 2015

11. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; focus on the nitric oxide pathwayAging395Heart failure with preserved ejection fraction develops when feeding western diet to senescence-accelerated mice396Cardiovascular markers as predictors of cognitive decline in elderly hypertensive patients397Changes in connexin43 in old rats with volume overload chronic heart failureGenetics and epigenetics400Calcium content in the aortic valve is associated with 1G>2G matrix metalloproteinase 1 polymorphism401Neuropeptide receptor gene s (NPSR1) polymorphism and sleep disturbances402Endothelin-1 gene Lys198Asn polymorphism in men with essential hypertension complicated and uncomplicated with chronic heart failure403Association of common polymorphisms of the lipoprotein lipase and pon1 genes with the metabolic syndrome in a sample of community participantsGenomics, proteomics, metabolomics, lipidomics and glycomics405Gene expression quantification using multiplexed color-coded probe pairs to determine RNA content in sporadic cardiac myxoma406Large-scale phosphorylation study of the type 2 diabetic heart subjected to ischemia / reperfusion injury407Transcriptome-based identification of new anti-inflammatory properties of the olive oil hydroxytyrosol in vascular endothelial cell under basal and proinflammatory conditions408Gene polymorphisms combinations and risk of myocardial infarctionComputer modelling, bioinformatics and big data411Comparison of the repolarization reserve in three state-of-the-art models of the human ventricular action potentialMetabolism, diabetes mellitus and obesity414Endothelial monocyte-activating polypeptide-II improves heart function in type -I Diabetes mellitus415Admission glucose level is independent predictor of impaired left ventricular function in patients with acute myocardial infarction: a two dimensional speckle-tracking echocardiography study416Association between biochemical markers of lipid profile and inflammatory reaction and stiffness of the vascular wall in hypertensive patients with abdominal obesity417Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening418Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity419Statins in the treatment of non-alcoholic steatohepatitis (NASH). Our experience from a 2-year prospective study in Constanta County, Romania420Epicardial adipose tissue as a predictor of cardiovascular outcome in patients with ACS undergoing PCI?Arterial and pulmonary hypertension423Dependence between heart rhythm disorers and ID polymorphism of ACE gene in hypertensive patients424Molecular mechanisms underlying the beneficial effects of Urocortin 2 in pulmonary arterial hypertension425Inhibition of TGf-b axis and action of renin-angiotensin system in human ascending aorta aneurysms426Early signs of microcirculation and macrocirculation abnormalities in prehypertension427Vascular smooth muscle cell-expressed Tie-2 controls vascular tone428Cardiac and vascular remodelling in the development of chronic thrombo-embolic pulmonary hypertension in a novel swine modelBiomarkers431Arrhythmogenic cardiomyopathy: a new, non invasive biomarker432Can circulating microRNAs distinguish type 1 and type 2 myocardial infarction?433Design of a high-throughput multiplex proteomics assay to identify left ventricular diastolic dysfunction in diabetes434Monocyte-derived and P-selectin-carrying microparticles are differently modified by a low fat diet in patients with cardiovascular risk factors who will and who will not develop a cardiovascular event435Red blood cell distribution width assessment by polychromatic interference microscopy of thin films in chronic heart failure436Invasive and noninvasive evaluation of quality of radiofrequency-induced cardiac denervation in patients with atrial fibrillation437The effect of therapeutic hypothermia on the level of brain derived neurotrophic factor (BDNF) in sera following cardiopulmonary resustitation438Novel biomarkers to predict outcome in patients with heart failure and severe aortic stenosis439Biological factors linking depression and anxiety to cardiovascular disease440Troponins and myoglobin dynamic at coronary arteries graftingInvasive, non-invasive and molecular imaging443Diet composition effects on the genetic typing of the mouse ob mutation: a micro-ultrasound characterization of cardiac function, macro and micro circulation and liver steatosis444Characterization of pig coronary and rabbit aortic lesions using IV-OCT quantitative analysis: correlations with histologyGene therapy and cell therapy447Enhancing the survival and angiogenic potential of mouse atrial mesenchymal cells448VCAM-1 expression in experimental myocardial infarction and its relation to bone marrow-derived mononuclear cell retentionTissue engineering451Advanced multi layered scaffold that increases the maturity of stem cell-derived human cardiomyocytes452Response of engineered heart tissue to simulated ischemia/reperfusion in the presence of acute hyperglycemic conditions453Serum albumin hydrogels prevent de-differentiation of neonatal cardiomyocytes454A novel paintbrush technique for transfer of low viscosity ultraviolet light curable cyan methacrylate on saline immersed in-vitro sheep heart [O] . V Garcia-Martinez, C Lopez Sanchez, W Hamed, 2016

12. THE EFFECTS OF PROCESSING ON PYROTECHNIC COMPOSITIONS PART III: DIMENSIONAL EFFECTS OF PAPER CASES ON I LUMINANCE AND BURNING RATE OF FLARE COMPOSITIONS [R] . Doris E. Middlebrooks, Seymour M. Kaye, Garry Weingarten 1966

1. 灵芝提取物对化疗预防和抗肿瘤作用特性物质在临床学上研究综述 [C] . 高益槐 ,周树峰 . 华东六省一市生物化学与分子生物学会2015年学术交流会 . 2015

2. 青钱柳、黑灵芝、独角莲中的活性物质对人源宫颈癌HeLa细胞的作用研究 [A] . 刘昕 . 2007