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NUCLEIC ACID MOLECULE AND METHOD OF TARGETING GENE EXPRESSION TO GLIOMAS
NUCLEIC ACID MOLECULE AND METHOD OF TARGETING GENE EXPRESSION TO GLIOMAS
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机译:核酸分子和靶向基因表达的胶质瘤方法
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摘要
There is presently provided a nucleic acid molecule comprising a glial-specific promoter; a coding sequence for a transgene; and a plurality of miRNA target sites. Each miRNA target site binds an miRNA that is down-regulated in .a glioma cell compared to a normal glial cell, and the glial-specific promoter and the plurality of miRNA target sites are both operably linked to the coding sequence for the transgene.
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