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INDUCEMENT OF ORGANOGENETIC TOLERANCE FOR PANCREATIC XENOTRANSPLANT
INDUCEMENT OF ORGANOGENETIC TOLERANCE FOR PANCREATIC XENOTRANSPLANT
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机译:胰腺异种植物的有机遗传耐受性诱导
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摘要
Provided herein is an approach to establish organogenetic tolerance via prior transplantation of pig embryonic pancreas, thereby enabling subsequent implantation of porcine islets in a subject without the need for immune-suppression. In one aspect of the invention, porcine pancreatic primordia are implanted into a mammalian subject, and after a period of time sufficient to induce tolerance, porcine islet cells are implanted in the subject.
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