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USE OF A MONOPHOSPHATE ESTER OF A PHTHALEIN COMPOUND AS A SUBSTRATE FOR TARTRATE-RESISTANT ACID PHOSPHATASE B5 (TRAP 5B)
USE OF A MONOPHOSPHATE ESTER OF A PHTHALEIN COMPOUND AS A SUBSTRATE FOR TARTRATE-RESISTANT ACID PHOSPHATASE B5 (TRAP 5B)
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机译:酞菁化合物的单磷酸酯作为抗酒石酸酸性蛋白酶B5的底物的用途(陷阱5B)
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摘要
The present invention relates to the use of a monophosphate ester of a phthalein compound as a substrate for Tartrate-Resistant Acid Phosphotase (TRAP). The substrate is used in assays for obtaining a measure of the amount of TRAP 5b in a sample of a subject, as an indication of the rate of bone resorption and therefore the likelihood of conditions such as osteoporosis. Also provided are kits comprising a monophosphate ester of a phthalein compound and optionally an antibody which binds total TRAP and methods.
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