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Crystal of a phosphatase of regenerating liver 1 (PRL-1) polypeptide and method of crystallization thereof
Crystal of a phosphatase of regenerating liver 1 (PRL-1) polypeptide and method of crystallization thereof
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机译:再生肝1(PRL-1)多肽的磷酸酶的晶体及其结晶方法
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摘要
The present invention relates to a crystal structure of PRL-1 (Phospatase of Regenerating Liver) protein and a method of crystallization thereof. It has been found that the PRL-1 protein has a tertiary structure having 5 strands of beta-sheet surrounded by 6 alpha-helices and well-arranged active site with closed P-loop, and monomers form a trimer through farnesylation site in the C-terminus of said protein. Thus intra-cellular migration and membrane localization can be achieved. The said crystal structure of PRL-1 protein of the present invention is very useful for the development the agent which inhibits carcinogenesis and metastasis of the cancer.
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