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ONE STEP NANOSENSOR FOR SINGLE AND MULTIDRUG RESISTANCE IN ACUTE CORONARY SYNDROME (ACS)

机译:急性冠脉综合征(ACS)的单药耐药和多药耐药的一阶纳米传感器

摘要

An embodiment relates to a method of detecting a drug resistance in a patient comprising adding nanoparticles to sample platelets to form activated platelets containing the nanoparticles and comparing a difference in activation of the activated platelets and the sample platelets. Another embodiment relates to a method of monitoring a thrombotic risk factor in a subject in a general population comprising adding nanoparticles to sample platelets to form activated platelets containing the nanoparticles and comparing a difference in activation of the activated platelets and the sample platelets. Yet another embodiment relates to a kit comprising nanoparticles, a fluorescence dye tagged antibody and optionally a buffer, wherein the kit is configured to detect a drug resistance in a patient or a likelihood of the thrombotic risk factor in a subject in general population.
机译:一个实施方案涉及一种在患者中检测抗药性的方法,该方法包括将纳米颗粒添加至样品血小板中以形成包含纳米颗粒的活化血小板,并比较活化血小板和样品血小板的活化差异。另一个实施方案涉及一种监测普通人群中受试者的血栓形成危险因素的方法,该方法包括将纳米颗粒添加至样品血小板中以形成包含纳米颗粒的活化血小板,并比较活化血小板和样品血小板的活化差异。另一个实施方案涉及一种试剂盒,其包含纳米颗粒,荧光染料标记的抗体和任选的缓冲液,其中该试剂盒被配置为检测患者的耐药性或普通人群中血栓形成危险因素的可能性。

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