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NANOSTRUCTURED SUBSTRATES FOR SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) AND DETECTION OF BIOLOGICAL AND CHEMICAL ANALYTES BY ELECTRICAL DOUBLE LAYER (EDL) CAPACITANCE
NANOSTRUCTURED SUBSTRATES FOR SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) AND DETECTION OF BIOLOGICAL AND CHEMICAL ANALYTES BY ELECTRICAL DOUBLE LAYER (EDL) CAPACITANCE
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机译:表面增强拉曼光谱(SERS)的纳米结构化基质,通过电双层(EDL)电容检测生物和化学分析物
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摘要
Provided according to embodiments of the invention are nanostructured surfaces that include a substrate; and an array of metallic nanopillar islands on the substrate, wherein each metallic nanopillar island includes a metal base layer on the substrate and a plurality of metallic nanopillars on the metal base layer, and wherein portions of the substrate between adjacent metallic nanopillar islands are free of the metal base layer. Also provided according to some embodiments of the invention are nanostructured surfaces that include a non-conductive substrate; and at least one nanoelectrode defined within the non-conductive substrate, wherein the at least one nanoelectrode is sized and/or shaped to immobilize an analyte or a probe molecule. Also provided are apparatuses and methods for SERS and detection of analytes or biological binding by EDL capacitance.
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