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PEPTIDES PROMOTING LIPID EFFLUX VIA ABCA1 AND ACTIVATING A LIPOPROTEIN LIPASE
PEPTIDES PROMOTING LIPID EFFLUX VIA ABCA1 AND ACTIVATING A LIPOPROTEIN LIPASE
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机译:通过ABCA1促进脂质流出并激活脂蛋白脂酶的肽
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摘要
Disclosed herein are peptides and peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway, as well as peptides that activate lipoprotein lipase, and compositions comprising such peptides or combinations thereof. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells and activate lipoprotein lipase within cells are also disclosed herein.
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