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Biological detection based on differentially coupled nanomechanical systems using self-sensing cantilevers with attonewton force resolution
Biological detection based on differentially coupled nanomechanical systems using self-sensing cantilevers with attonewton force resolution
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机译:基于具有牛顿力分辨力的自感应悬臂的基于差分耦合纳米机械系统的生物检测
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摘要
A biosensor is comprised of a free and a biofunctionalized recognition self-sensing nanocantilever, a dock adjacent to the ends of the nanocantilevers, and a gap between the nanocantilevers and dock. The self-sensing cantilevers each include a semiconductor piezoresistor defined in a pair of legs about which the cantilevers flex. A bias power or current is applied to the piezoresistor. The sensitivity of the cantilevers is optimized for a given ambient temperature and geometry of the cantilevers and dock by minimizing the force spectral density, SF, of the cantilevers to determine the optimum bias power, Pin. A sub-aN/√Hz force sensitivity is obtained by scaling down the dimensions of the cantilevers and supplying an optimum bias power as a function of temperature and geometry.
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机译:生物传感器包括一个自由的和生物功能化的识别自感应纳米悬臂,一个邻近纳米悬臂末端的基座以及纳米悬臂与基座之间的间隙。每个自感测悬臂包括限定在一对腿中的半导体压敏电阻,悬臂绕其弯曲。偏置功率或电流施加到压阻器。通过最小化悬臂的力谱密度S F Sub>来确定最佳偏置功率P ,针对给定的环境温度和悬臂和停靠件的几何形状优化悬臂的灵敏度在 Sub>中。通过缩小悬臂的尺寸并根据温度和几何形状提供最佳偏置功率,可以获得低于aN /√Hz的力灵敏度。
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