Process for {3-2(R)-(1R)-1-3,5-bis(trifluoromethyl)phenylethoxy-3(S)-(4-fluorophenyl)morpholin-4-ylmethyl-5-oxo-4,5-dihydro-1,2,4-triazol-1-yl}phosphonic acid

摘要

The present invention is concerned with a process for the preparation of the compound {3-[2(R)-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl) -morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid, and pharmaceutically acceptable salts thereof. This compound is useful as a substance P (neurokinin-1) receptor antagonist. In particular, the compound is useful e.g., in the treatment of emesis and inflammatory diseases.