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Nontypeable Haemophilus influenzae virulence factors

机译：不可分类的流感嗜血杆菌毒力因子

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摘要

The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. The invention also relates to a novel 110 kDa NTHi outer membrane protein and the polynucleotide that encodes this outer membrane protein. Methods of screening for NTHi infection, and treating and preventing NTHi related disorders are also contemplated. 展开▼

机译：本发明涉及流感嗜血杆菌（NTHi）的无型菌株无毒克隆的汁液操纵子中的突变。本发明还涉及NTHi sap操纵子基因和由这些多核苷酸序列编码的多肽。本发明还涉及新颖的110kDa NTHi外膜蛋白和编码该外膜蛋白的多核苷酸。还考虑了筛选NTHi感染以及治疗和预防NTHi相关疾病的方法。 展开▼

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公开/公告号US7901692B2

专利类型

公开/公告日2011-03-08

原文格式PDF

申请/专利权人 LAUREN O. BAKALETZ;ROBERT S. MUNSON JR.;
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申请/专利号US20100761074

发明设计人 LAUREN O. BAKALETZ;ROBERT S. MUNSON JR.;
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申请日2010-04-15

分类号A61K39/102;

国家 US

入库时间 2022-08-21 18:07:57

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1. 不可分型流感嗜血杆菌疫苗和它们的用途 [P] . 中国专利： CN102159225B . 2013.11.13

2. 不可分型流感嗜血杆菌疫苗和它们的用途 [P] . 中国专利： CN102159225A . 2011-08-17

3. Nontypeable Haemophilus Influenzae Virulence Factors [P] . 美国专利： US2011223174A1 . 2011-09-15

机译：非分型流感嗜血杆菌毒力因子

4. Nontypeable Haemophilus Influenzae Virulence Factors [P] . 美国专利： US2010196382A1 . 2010-08-05

机译：非分型流感嗜血杆菌毒力因子

5. Nontypeable Haemophilus influenzae virulence factors [P] . 美国专利： US7723504B2 . 2010-05-25

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10. Identification of the Lipooligosaccharide Biosynthesis Gene lic2B as a Putative Virulence Factor in Strains of Nontypeable Haemophilus influenzae That Cause Otitis Media [O] . M. M. Pettigrew, B. Foxman, C. F. Marrs, 2002

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