Process for total synthesis of pladienolide B and pladienolide D

摘要

Process for producing compound of Formula:; wherein P², P³ and R² are the same as defined below, characterized by comprising reacting a compound represented by Formula (7):; wherein P³ means a protecting group for hydroxy group; and Het means a 1-phenyl-1H-tetrazol-5-yl group, with a compound represented by Formula (8):; wherein P² means a protecting group for hydroxy group; and R² means a phenyl group which may be substituted, in the presence of a base.