Derivatives of arilciclohexileteres 5,6 dihydro - 4 - 2,3,5,10 - B - Chemicals - benzo e Azulene, Pharmaceutical compositions containing Same, Preparation Process and Use thereof in sexual Dysfunctions and disorders of the CNS, among other pathologies.

摘要

The compounds of the invention act as modulators of The Pathway of receptor and Receptor Antagonists, in particular as the route; The Invention further refers to its acquisition, Pharmaceutical compositions containing them and their use as medicines.The active compounds of the present Invention are useful as therapeutic agents acting at Peripheral and central level in Pathological States such as dysmenorrhea, male or Female Sexual Dysfunction, hypertension, Chronic Heart Failure, inappropriate secretion of vasopr Resin, Liver cirrhosis, nephrotic syndrome, anxiety, Depressive Disorders, obsessive-compulsive Disorder,Autistic Spectrum Disorders, Schizophrenia and Aggressive Behaviour.Claim 1: The Compound of the General formula (1) wherein R1 is aryl or heteroaryl, without replacing or replaced by one or more substituents selected Independence between alkyl; R2 is H, or C1 - 12, without replacing replaced by one or more Oh, halogen, alkoxy or cyano C1 - 12 - Q - (CH2) IN RA, the ra is phenyl or heteroaryl 5 or 6 layersEach of them is no substitute or substituted by one or more substituents selected Independence between a - (CH2) rnririi, - C (o) - alkyl alkyl C1 C1 - 12, - 12 without replacing or is replaced by one or more Oh, halogen, alkoxy or cyano C1 - 12, - C (o) (CH2) (QOC) - C1 - 12 alkyl, - C (o) - (CH2) Qnririi, - C (o) or alkyl C1 - 12, the rent is no substitute or substituted by one or more Oh, halogenCyano or alcosi C1 - 12, - S (o) 2 - alkyl of C1 - 12, - S (o) 2nririi, RI and RII with Independence among c1-12 is H, alkyl, or with Nitrogen, which together form a heterocicloalquilo 3 to 7 links containing one or dods heteroatoms selected from N, o and S, Said heterocicloalqui Is no substitute or substituted by one or more substituents elected for Independence between BQ is the Number 1, 2, 3 or 4, R is the Number 2, 3 or 4 is Halogen, alkyl, cyano, Oh, haloalquilo C1 C1 - 7, 7, 7 haloalcoxi alkoxy C1, C1 and C1 - 7 - 7 Hydroxy alkyl, B is oxo Halogen, oh alkyl or alkoxy C1 C1 - 7 - 7, R3 is cl or F, or a pharmaceutically acceptable Salt thereof.